CSVP 371 Diagnosis
Jun 14, 2019
本次會議組織病理切片資訊：
http://140.120.114.107/slidecenter.php?id=455
Case 1. CSVP 2019-3037 (BN19004, ADDC NCYU, Y. T. Wang, H.C. Kuo, C.L. Chen, Y.C. Su, M.H. Chang, and D.Y. Lo)
Suckling pigs, 10- day-old, were submitted to ADDC for disease diagnosis. The pigs showed clinical sign of yellowish watery diarrhea. The cumulative morbidity rate was 50 % and mortality rate was 25%.
Morphological diagnosis:
1. Gastritis, necrotizing , hemorrhagic, diffuse, acute, severe
2. Enteritis, necrotizing, hemorrhagic, segmental, acute, severe
Laboratory examinations:
TSC agar: black colonies
PCR: C. perfringens – CPA gene 900 bp (+);CPB gene 611 bp (+)
Etiological Dx.
Infection of Clostridium Perfringens Type C in Suckling Pigs
Case 2. CSVP 2019-3038 (NTU2019-684, NTU GIMCP, C.H. Shih and W.T. Li)
Feline, DSH, female, 1-year-old, showed ataxia, head tremor and neurological signs for 2 weeks. Poor prognosis was concerned thus euthanasia was performed.
Morphological diagnosis:
1. Meningoencephalomyelitis, pyogranulomatous, diffuse, severe, with severe vasculitis, cerebrum, brainstem, cerebellum, and spinal cord
2. Nephritis, pyogranulomatous, multifocal, severe, with multifocal cortical interstitial fibrosis and tubular atrophy/regeneration, kidney
3. Colitis, pyogranulomatous, multifocal and transmural, severe, colon
4. Lymphadenitis, pyogranulomatous, multifocal, severe, mesenteric lymph node
5. Pancreatitis, fibrotic and lymphoplasmacytic, locally extensive to diffuse, moderate, with ductal hyperplasia and hemorrhage, pancreas
6. Hepatitis, portal, multifocal, lymphoplasmacytic, with centrilobular degeneration (fatty change), moderate, liver
7. Panophthalmitis, pyogranulomatous, locally extensive, moderate, eyeballs
8. Pneumonia, pyogranulomatous, multifocal, mild, lung
Lab examined;
IHC; FIP (+)
Etiological Dx.
Feline Infectious Peritonitis
Case 3. CSVP 2019-3039 (NTU2018-2960F, NTU GIMCP, C.F. Kao, W.H. Huang, and C.H. Liu)
Canine, Maltese, 14-year-old, castrated male. Chronic hypoglycemia and seizure episodes (trembling, facial muscle twitching, salivation & loss of consciousness) were noted. During hospitalization, blood tests revealed severe hypoglycemia, and the patient showed poor response to glucocorticoid treatment or 2.5%-5% glucose supplement.
Morphological diagnosis:
1. Islet cell carcinoma, most likely insulinoma /islet /islet β cell cell carcinoma, with metastases to mesenteric lymph carcinoma, with metastases to mesenteric lymph nodes and liver, pancreas
2. Cortical laminar necrosis and neuronal degeneration, segmental and superficial, with mild to moderate gliosis, satellitosis and edema, cerebral cortex and edema,
3. Pituitary adenoma, most likely nonfunctional, chromophobe adenoma in pars adenoma, distalis of pituitary gland
Etiological Dx.
Hypoglycemic Encephalopathy in a Maltese
Case 4. CSVP 2019-3040 (NTU2019-902I, NTU GIMCP, Y.H. Hsieh and W.T. Li)
Feline, mongrel, 11-year-old, castrated male. Acute onset of circling to Rt. side, bump to something and head pressing was noted. According to neurological examination, lesion localization was forebrain and brainstem.
Morphological diagnosis:
1. Carcinoma, undetermined origin, most likely choroid plexus carcinoma, with metastasis to the bilateral cervical lymph nodes and Rt. submandibular lymph node, Rt. frontal lobe and lateral ventricle, cerebrum
2. Atypical alveolar hyperplasia, multifocal, with multifocal, severe arterial medial hypertrophy, lung
3. Lipoid pneumonia, multifocal, subacute, mild, lung
4. Exocrine adenoma, pancreas
IHC: CK, vimentin, CK19, pan CK (+); S-100, GFAP, TTF-1, p63 (-)
Etiological Dx.
Choroid Plexus Tumors in a cat
5. CSVP 2019-3041 (CS19-04151B, GIVP NCHU, F.Y. Tsai, J.W. Liao, and H.Y. Chiou)
Canine, Dalmatian, 13-year-old, neutered female. A fast-growing mass was found on the right upper lip for 1.5 months.
Morphological diagnosis:
1. un-encapsulation, round to spindle, pseudorosettes and tumor cells were found in the subcutaneous mass. Some of them contained with brownish melanin, most of the tumor cells were amelanotic melanoma.
2. Junctional activity: single cell or nests in basal portion of epidermis
3. Pagetoid infiltration: invade upper epidermis from stratum basale (not seen in melanocytoma)
4. Pagetoid infiltration: invade upper epidermis from stratum basale (not seen in melanocytoma)
IHC: Melan-A (AEC) (+)
Etiological Dx.
Amelanotic melanoma in a Dalmatian dog
Case 6. CSVP 2019-3042 (CP19-0404B, GIVP NCHU, Y.C. Cheng, W. Chen, J.H. Shien, and H.Y. Chiou)
Broilers, 7-day-old, showed clinical signs of weakness, lameness and adherence of feces to the vent. The culling rate was approximately 7% (3,500/50,000).
Morphological diagnosis:
1. Heart: epicarditis, multifocal, moderate, acute
2. Liver and spleen: Hepatitis, necrotizing, multifocal, moderate, acute
3. Spleen: Splenitis, necrotizing, multifocal, moderate, acute
Laboratory result:
Heart, liver, yolk sac: Salmonella sp. (+) & Escherichia coli (+)
Etiological Dx.