2018-5-4 CSVP 362 Diagnosis

本次會議組織病理切片資訊：

http://140.120.114.107/slidecenter.php?id=434  

Case 1. CSVP 2018-2983 (NTU2017-2564, NTU, W.T. Li, M.S. Tsai, C.R. Jeng)

Taiwan japalure (Japalura swinhonis), adult, female. The animal was found in the cage of captive elongated tortoises (Indotestudo elongata) in Taipei Zoo. The animal became lethargic, lay down on the floor, and found dead.

Morphological diagnosis:

1.         Dermatitis, severe, subacute to chronic, multifocal, hyperkeratotic, heterophilic and granulomatous, with intralesional gram-positive filamentous bacteria compatible with Dermatophilus spp., skin

2.         Sarcocystis and myodegeneration, skeletal muscle

Etiological Dx.

Dermatophilosis in a wild Taiwan japalure

Case 2. CSVP 2018-2984 (NTU2017-2010, NTU GIMCP, C.S. Hsueh, C.R. Jeng)

Malay tapir馬來貘(Tapirus indicus), 13-day-old, male. The animal was weak, could not stand and eventually died.

Morphological diagnosis:

1.         Disseminated intravascular coagulation, with associated hemorrhage, edema, necrosis and degeneration, heart, spleen, lungs, kidneys, adrenal glands, gastrointestinal tracts

2.         Hepatocellular necrosis and hepatic hemorrhage and portal lymphoplasmacytic hepatitis, multifocal to coalescent, liver

3.         Encephalopathy with perivascular edema and thrombi formation, brain

4.         Pulmonary congestion and edema, mild, acute, diffuse, lungs

5.         Meninges: Salmonella group

Etiological Dx.

Salmonellosis in a Malayan tapir (Tapirus indicus)

Case 3. CSVP 2018-2985 (SW2018-003, NTU GIMCP, Y.H. Hsieh, F.C. Hsueh, H.W. Chang) Swine, 5-week-old, showed clinical signs of post-weaning diarrhea since December, 2017. The pigs appeared redness around anus and systemic cyanosis after diarrhea. Morbidity and mortality rate were about 80% and 70-80%, respectively.

Morphological diagnosis:

1.         Enteritis, diffuse, subacute, moderate, with bacillus colonization adhesion and goblet cells hyperplasia, small intestine

2.         Mucoid degeneration and lymphoid depletion, Ileocecal valve

Etiological Dx.

Postweaning diarrhea caused by enterotoxigenic E. coli (ETEC) with F18 adhesins

Case 4. CSVP 2018-2986 (C017-810-201J, GIVP NCHU, Y.H. Su, Y.X. Lin, Y.C. Tuan, J.W. Liao)

Rat, Sprague Dawley, 10-week-old, male, was treated with tyrosine kinase inhibitor, sorafenib for 28 days by gavage. The clinical signs of weight loss, depression and rough fur were noted

Morphological diagnosis:

1.     Growth plate and articular cartilage: Proliferation and hypertrophy of chondrocytes, diffuse, severe, chronic

2.     Bone marrow: Hypocellularity, diffuse, moderate/severe, chronic

3.     Ovary: Follicle increase, multifocal, moderate, chronic

4.     Spleen: Atrophy, diffuse, moderate, chronic

Etiological Dx.

Sorafenib-associated multi-organ toxicity

Case 5. CSVP 2018-2987 (R2018-008A, GIVP NCHU, J.H. Yin, Y.C. Chang. H.Y. Chiou, J.W. Liao)

Formosan serow (Capricornis swinhoei), adult, intact female. Within 3 months, three sudden deaths of Formosan serows were found. Grossly, the lung lobes were diffusely mottled red to dark brown in color, heavy and wet.

Morphological diagnosis:

1.   Lung: Vasculitis, necrotizing, lymphoplasmacytic, multifocal, subacute, severe, occasionally with fibrinous thrombi,  fibrinosuppurative, granulomatous bronchopneumonia, interstitial pneumonia

2.   Primer targeting Malignant catarrhal fever (Ovine Herpesvirus 2)

Etiological Dx.

Malignant catarrhal fever in a Formosan sorrow

Case 6. CSVP 2018-2988(APL001-C3, TACTRI, C.L. Liao, H.R. Lin, C.H. Yang, J.W. Liao, H.Y. Chiou)

Mice, C57BL/6(B6), 13-week-old, male. Mice were fed with the Lieber-DeCarli ethanol liquid diet for 4 weeks to establish alcoholic liver disease (ALD) animal model.

Morphological diagnosis:

1.         Fatty change, macrovesicular and microvesicular, diffuse, severe, chronic active with mild multifocal hepatitis, alcohol induced, liver.

Etiological Dx.