2017-11-3 CSVP 358 Diagnosis

本次會議組織病理切片資訊：

http://140.120.114.107/slidecenter.php?id=416             

Case 1. CSVP 2017-2959 (106035-A, NTUCMLAC, Y.T. Tsai, C.Y. Chang, W.P. Chen, H.W. Chen)

Disc1 eml transgenic mouse, 4.5-month-old, female. The mouse presented abdominal Swelling. The unilateral 5 x 4 x 4 cm ovarian mass was noted at necropsy.

Morphological diagnosis:

1.         Ovary: The presence of all 3 germ layers: keratinized, bone, bronchial, with neuro tissue were noted.

2.         Spleen, bone marrow and liver: Morphology and IHC results: Erythroid leukemia

3.         Erythroid leukemia (Rubriblast and prorubricyte) : CD71

Etiological Dx.

Ovarian Teratoma and Erythroid Leukemia in a Disc1 Transgenic Mouse

Case 2. CSVP 2017-2960 (NTU2015-2786, NTU, Y.H Hsieh, W.T Li, V. F. Pang, C.R. Jeng, C. H. Liu, F.I. Wang, H.W. Chang)

Canine, mongrel, 10-year-old, male castrated. Patient suddenly vomited 2 days ago. Lethargy, anorexia, icterus and occasional cyanosis were noticed after then. Laparotomy was performed on 10/26/2015. Liver was found extremely enlarged 2 location of ileum wall was thickened, wedge biopsy were performed.

Morphological diagnosis:

1.         Lymphoma, specimens from liver and ileum

2.         CD3 (+); CD79a (-)

Etiological Dx.

Hepa1tocytotropic T-cell Lymphoma in A Dog

Case 3. CSVP 2017-2961 (NTU2016-1987, NTU GIMCP, C.H. Shih, B.Y. Liou, W.T. Li, F. I. Wang )

Goat, Alpine, 3~4-month-old, castrated, was presented with dysuria about 4 days. Urinalysis revealed glucosuria and proteinuria. Hematology and blood chemistry exams revealed leukopenia (3,200/ul), elevated BUN (158 mg/dL) and creatinine (8.2 mg/dL). Urinary bladder distention was found in abdominal radiography. Urethral catheterization was performed but failed. Antimicrobial, analgesics and IV fluid therapy was prescribed, however, the patient was found dead on the next day.

Morphological diagnosis:

1.     Urethral stenosis, most likely congenital, urethra (Gross diagnosis)

2.     Urethritis, hemorrhagic and suppurative, diffuse and transmural, subacute, severe, urethra

3.     Cystitis, hemorrhagic and suppurative, multifocal and transmural, subacute, severe, urinary bladder

4.     Pelvic hemorrhage, locally-extensive, acute, moderate, kidney

5.     Bronchopneumonia, suppurative, locally extensive, acute, moderate to severe, with pulmonary edema and disseminated intravascular coagulation, lung

6.     Epicardial hemorrhage, locally-extensive, acute, moderate, with involvement of beneath myocardium, heart

Etiological Dx.

Congenital urethral stenosis with secondary bacterial infection in an alpine goat

Case 4. CSVP 2017-2962 (CE17022, ADDC NCYU, Y.U. Liao, H.C Kuo, C.L. Chen, Y.C. Su, M. H. Chang, D.Y. Lo)

Chicken, Ross Cobb, 17-day-old, showed clinical signs of depression, gasping, dyspnea and the daily chicken death was about 20

Morphological diagnosis:

1.     Trachea: Tracheitis, multifocal, mild, subacute.

2.     Kidney: Nephritis, multifocal, mild, subacute.

3.     IBV, Avian nephritis virus structure protein 99% (+)

Etiological Dx.

Co-Infection of Infectious Bronchitis and Avian Nephritis virus in Ross broilers

Case 5. CSVP 2017-2963 (CO17-460, GIVPNCHU, Y.H. Su, F.Y. Tsai, Y.X. Lin, Y.C. Tuan, H.Y. Chiou, J. P. Kao, J.W. Liao)

Hamster, 2-year-old, intact male. A mass was found in left abdomen, while no calculus image under radiography. After laparotomy, a mass (about 1x1 cm) was noted on the left kidney.

Morphological diagnosis:

1.   mixture of embryonal epithelial (tubule, glomeruli), blastemal, mesenchymal tissues, the most diagnostic of which are embryonic glomeruli.

2.   Tufts of epithelium invaginate into a lumen to form glomeruloid structures

3.   Mesenchymal blastoma: Vimentin (+); CK (-)

4.   embryonal epithelial (tubule, glomeruli): tubule : CK19 (+); vimentin (+)

5.   Stromal cells: Vimentin, desmin (+)

Etiological Dx.

Nephroblastoma in a hamster

Case 6. CSVP 2017-2964 (CO17-497A, G, H.K. Chang, C.C. Lin, S.T. Chuang, Y.L. Lin, H.Y. Chiou)

Goat, 0.5-year-old, had been fed with high protein concentrates since 3 months ago. They clinically showed salivation, Swollen mandible and dystasia. In serum biochemistry test, the parathyroid hormone (PTH) of the necropsied goat was 226.9 pg/mL. (In late pregnancy, secretion rates of 0.7-0.9 ng/kg per min)

Morphological diagnosis:

Thyroid: hypertrophy and hyperplasia

Facial bone: Osteodystrophia fibrosa, increase number in the osteoclast cells

Etiological Dx.

Suspected nutritional hyperparathyroidism