中華民國獸醫病理學會

CSVP 411 diagnosis

May 19, 2025

411 CSVP Contributor Diagnosis

Date: May 16, 2025
Time: 12 : 00~16 : 00
Place: NCHU
專題演講(12:00~13:00)：人工智慧於數位毒性病理學之應用 (廖俊旺老師)
本次會議組織病理切片資訊：http://140.120.114.107/slidecenter.php?id=554

切片名稱：Case 1. NTU24-2209B
Case 1. CSVP 2025-3278 (NTU2024-2209, NTU GIMCP, H.H. Yeh, C.H. Shih, and H.W. Chang)
Feline, mixed, spayed female, 9-year-old. The patient had hematochezia in October 2024, improving temporarily with Augmentin. A December 2 colonoscopy revealed a polyp-like mass at the cecum-ileum junction. A partial polyp excision failed, leading to surgical resection of the distal ileum and proximal ascending colon with anastomosis.
Morphologic diagnosis :
distal ileum and proximal ascending colon:
Intestinal duplication, the polyp-like mass on the junction of distal ileum, proximal ascending colon and cecum
Lab. examination:
Dx: Intestinal duplication in a cat

切片名稱：Case 2. A112-015-1-2
Case 2. CSVP 2025-3279 (A112-015-1-2, ADDC NPUST, S.H. Ma, Y.H. Hsieh, Y.W. Tsai, Y.C. Li, and M.C. Cheng)
Broiler, 21-day-old. The cumulative mortality rate began to increase gradually from day 19 of age, reaching approximately 1.7% (1,240/74,000). Necropsy on day 19 revealed hepatic steatosis and hepatic hemorrhages..
Morphologic diagnosis :
Liver: hepatitis, necrotic, moderate, subacute, multifocal, with basophilic intranuclear inclusion bodies
Kidney : nephritis, interstitial, mild, subacute, multifocal
Heart : myocarditis and epicarditis, granulomatous, severe, chronic, locally extensive
Trachea : Tracheitis, lymphocytic, mild, chronic, multifocal
Muscle: Necrosis, multifocal, moderate, acute
Lung: NSL.
Lab. examination:
1.     PCR: Fowl aviadenovirus (FAdV): (+); Infectious bronchitis virus (IBV): (-)
2.     Bact: Salmonella spp (+++)
Dx: Inclusion body hepatitis (IBH) and Salmonellosis in broilers

切片名稱：Case 3. D113-550-4
Case 3. CSVP 2025-3280 (D113-550, ADDC NPUST, H.W. See, Y.H. Hsieh, C.H. Yan, and Y.C. Li)
Piglet, 3-day-old, showed clinical signs including weakness, underweight, and yellowish diarrhea. Piglets aged 2-3 days appeared weak and underweight, with sudden death occurring at 4-5 days of age. The incidence rate was 5%, and the mortality rate reached 30%.
Morphologic diagnosis :
Colon: Colitis, severe, acute, segmental, erosive, with rod-shape bacteria in erosive area, and submucosal and serosal edema
Stomach: Gastritis, multifocal, mild, acute
LN: brown pigmentation, peripheral, multifocal, acute, suspected iron injection at birth day
Jejunum: NSL
Lab. examination:
Mesentery Anaerobic culture : Clostridium difficile (+)
Ileal content: RT-PCR: Rotavirus (A/B/C), PEDV, TGEV, SDCov (-)
Dx: Clostridium Difficile Infection in Suckling Piglets

切片名稱：Case 4. 114-20010
Case 4. CSVP 2025-3281 (114-20010, NIAR NCB, T.Y. Chen, K.H. Lee, and H.H. Sung)
Genetically modified mouse, 7.5-month-old, female. The untreated GM mouse showed hypoactivity, weight loss, hunched posture, chronic wasting and poor reproductive performance.
Morphologic diagnosis :
Kidney: Hydronephrosis, pelvic, focal, moderate, chronic, bilateral
Tubular dilation and glycogen nuclei, moderate.
Glomeruli hypertrophy, mild
Mesangial matrix expansion (diffuse), mild
Diffuse thickening of glomerular, tubular and Bowman capsule thickening membranes, mild to moderate.
Tubulointerstitial fibrosis, minimal
Ureter: Dilation, obstructive, diffuse, moderate, chronic
Lab. examination:
Clinical Chemistry (Non-fasted samples)
Urinalysis (Urine test strip)
Glucose: >2000 ++++ mg/dL
Protein: 30 mg/dL +
SG: 1.030
Dx: Diabetic nephropathy, mild, with cytopathy, moderate bilateral hydronephrosis and hydroureter

切片名稱：Case 5. 113015
Case 5. CSVP 2025-3282 (113015, NTUCM LAC, Y.T. Tsai, I.S. Yu, and W.P. Chen)
Mouse, Brca1 (breast cancer associated gene 1) knockout, 10-month-old, female. The mouse revealed periocular and external auditory swelling, and a 1×0.8×0.8 cm, hyperkeratotic warty cutaneous mass.
Morphologic diagnosis :
Haired skin : Squamous cell carcinoma
External auditory canal : Squamous cell carcinoma
Harderian gland, left side : Adenocarcinoma
Harderian gland, right side : Adenocarcinoma arising in cystic adenoma
Lab. examination:
Dx: Mouse model of Brca1 deficiency

切片名稱：Case 6. CM24-09013C
Case 6. CSVP 2025-3283 (CM24-09013, ADDC NCHU, Y.C. Hsu, Y.H. Lee, and H.Y. Chiou)
Nursery pigs, 8- to 9-week-old, showed clinical signs including growth retardation, occasional coughing, diarrhea, and icterus. The monthly mortality rate was below 5% with about 20-30% of the nursery pigs showing signs emaciation.
Morphologic diagnosis :
Lymphoid nodes: Lymphadenitis, granulomatous and eosinophilic, moderate to severe, diffuse, chronic, with severe lymphoid depletion, and basophilic intrahistiocytic cytoplasmic botryoid inclusion bodies.
Ileum: Ileitis, mild to moderate, diffuse, chronic, with mild villous blunting, marked lymphoid depletion, and basophilic intrahistiocytic botryoid inclusion bodies.
Cecum: Typhlitis, necrohemorrhagic and ulcerative, moderate, multifocal to coalescing, chronic, with intralesional Balantidium coli.
Colon: Colitis, necrohemorrhagic and ulcerative, moderate, multifocal to coalescing, chronic.
Tonsil: Lymphoid depletion, moderate, diffuse, with basophilic intracytoplasmic botryoid inclusion bodies.
Liver: Hepatitis, lymphohistiocytic, mild, multifocal, chronic.
Lungs: Interstitial pneumonia, lymphohistiocytic, mild, multifocal, chronic.
Lab. examination:
Polymerase chain reaction (PCR):
Porcine Circovirus Type 2 (PCV2): Positive
Mycoplasma suis (Eperythrozoon suis; EPY): Negative
Immunohistochemistry (IHC): Peyer’s patch= PCV2 (+)
Microbiological Examination: Intestines: Escherichia coli (+)
qPCR:
Dx: Porcine Circovirus Type 2 Systemic Disease (PCV2-SD) in Nursery Pigs

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